El Ciclo de Krebs / Rap Medicina

Krebs cycle

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Acetyl-CoA is condensed
And Oxaloacetate
Citrate is formed by the enzyme Citrate Synthase
And the Citrate is dehydrated
Forming Cis-Aconitate by the enzyme Aconitase
And it goes through the same enzyme Aconitase

Sis-Aconitate with H2O is hydrated
And when hydrated it forms Isocitrate
And an oxidation forms Oxalosuccinate
But what was the oxidation enzyme? Isocitrate dehydrogenase this time
I highlight a fact in this action
The first 3 ATPs in this reaction

Oxalosuccinate is decarboxylated, reaction
Which is produced through the same enzyme
And it becomes Alpha-ketoglutarate
It's not complicated, learn the rookie cycle

Alpha ketoglutarate converts to succinyl-CoA by oxidative decarboxylation
Enzyme that this process has a place
Active alpha-ketoglutarate dehydrogenase
And, at this stage of the Krebs Cycle
3 ATPs are produced again
While Succinyl-CoA forms the
Succinate why it is phosphorylated
At the substrate level

When Succinyl-CoA then passes to Succinate, through the enzyme Succinyl-CoA Thiokinase
An ATP is released in the process
Come on, buddy, to the cycle
You know about that

Succinate becomes Fumarate
By oxidation producing 2 ATPs in release
Succinate dehydrogenase
With its introduction, it was the enzyme
That he had participation there

Fumarate turns into Malate when
It is hydrated by carrying out a process
By the enzyme Fumarase
And the Malate oxidizes and for the moment
It happens, the Malate dehydrogenase acts

Then the Malate returns to Oxaloacetate, releasing 3 ATPs
In just a little while
Then follow the process as
Start at the beginning and Acetyl-CoA comes again and
The cycle repeats itself